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We verified dimer formation and in-vitro activity of purified recombinant wild-type and mutant GSAAT At

(PubMed) Dorant E, van den Brandt PA, Goldbohm RA

10.1016/j.freeradbiomed.2020.12.012 Free Radic

In contrast, miR-27a promotes mitophagy by targeting USP14, destabilizing BAG4, and enhancing 5-FU sensitivity in MSI-high CRC [122]

Here, we summarized the role of the vicious cycle of mitochondrial damage and ROS accumulation in RA and introduced potential drugs that target mitochondria or scavenge ROS for RA treatment, with the aim of providing some help for the clinical treatment of RA ( Table 1 )